Angiotensin converting enzyme 2 level and its significance in COVID-19 and other diseases patientsMeta-Analysis Published on 2023-01-012023-07-10 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), [키워드] cardiovascular diseases membrane-bound ACE2 RAS SARS-CoV2 soluble ACE2. [DOI] 10.1111/eci.13891 PMC 바로가기 [Article Type] Meta-Analysis
Population Risk Factors for Severe Disease and Mortality in COVID-19 in the United States during the Pre-Vaccine Era: A Retrospective Cohort Study of National Inpatient SampleArticle Published on 2022-12-042023-07-11 Journal: Medical Sciences [Category] COVID19(2023년), [키워드] cardiovascular diseases COVID-19 complications COVID-19 mortality COVID-19 risk factors national inpatient sample (NIS) socioeconomic disparities. [DOI] 10.3390/medsci10040067 PMC 바로가기
Modeling Cardiac SARS-CoV-2 Infection with Human Pluripotent Stem CellsReview Published on 2022-12-012023-07-10 Journal: Current cardiology reports [Category] COVID19(2023년), [키워드] cardiovascular diseases COVID-19 disease modeling iPSC. pluripotent stem cells SARS-CoV-2 [DOI] 10.1007/s11886-022-01813-2 PMC 바로가기 [Article Type] Review
Investigation of the effect of COVID-19 on sperm count, motility, and morphologyArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome Adana analyzed angiotensin-converting enzyme 2 both group cardiovascular diseases cause Cell changes in city Commission Concentration control group coronavirus COVID-19 COVID-19 negative decision disease Diseases Effect Ethics ethics committee expressed Fertility group high affinity individual investigation large sample Lungs male men Ministry of Health morphology parameters positive receptor respiratory diseases SARS-CoV-2 selected Semen semen sample shown significantly higher single-stranded RNA virus sperm parameters. statistically significant difference the patient the SARS-CoV-2 tissue training university with COVID-19 World Health Organization [DOI] 10.1002/jmv.27971 PMC 바로가기
Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular MechanismsArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] 신약개발, 진단, [키워드] accompanied activity addition aging all-cause mortality animal model animal models available data benefit Biomarker blunt caloric restriction calories cardiovascular diseases Cardiovascular outcomes cellular senescence clinical study clinical trials Compound COVID-19 decrease diabetes driver drug drugs employment Evidence Fatty acid feature Glucose heart failure humans IL-6 independent inflammaging Inflammasome inhibitor inhibitors intrinsic Kidney disease low-grade inflammation meta-analysis modulating modulation molecular Mortality nutrient-sensing pathways observational studies outcomes pathway Patient promote provided repurposing selected senescence sodium-glucose cotransporter 2 inhibitors. substrates suggested Support systemic effects systemic level target Urine [DOI] 10.3390/ijms232012325 PMC 바로가기
A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study)Article Published on 2022-09-272022-11-15 Journal: BMC Medicine [Category] SARS, 진단, [키워드] 95% confidence interval Administered age airway analysis asymptomatic patients Bayesian camostat camostat mesilate cardiovascular diseases cells Chronic kidney disease chronic respiratory disease clinical conducted consecutive negative test conversion COVID-19 COVID-19 symptom Diabetes Mellitus dose double-blind Drug screening effective Efficacy and safety eight enrolled evaluate Factor first test hospital human airway epithelial hypertension indicated Japan median time Mild moderate multicenter no significant difference obesity parallel-group Patient patients patients with COVID-19 Placebo placebo-controlled study Positive test Prevent primary efficacy endpoint Randomized Randomized controlled trial receive reduce registry SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. the placebo group the primary endpoint Treatment two groups underlying disease viral clearance viral loads was performed were blinded were excluded without symptoms [DOI] 10.1186/s12916-022-02518-7 PMC 바로가기
Serum biomarkers associated with SARS-CoV-2 severityArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] acute phase Angiogenesis Asymptomatic biological marker Biomarker cardiovascular diseases chemokine Clinical course controls correlated cytokine D-dimer disease disease severity elevated evaluated Factor group groups Growth factors help Hospitalized identify immune response individual infected with SARS-CoV-2 Infection Mild negative control Patient patients with SARS-CoV-2 prognostic Prognostic markers RT-PCR SARS-CoV-2 SARS-COV-2 infection sera Severe case severity [DOI] 10.1038/s41598-022-20062-5 PMC 바로가기
The Variation of Transcriptomic Perturbations is Associated with the Development and Progression of Various DiseasesArticle Published on 2022-09-262022-11-16 Journal: Disease Markers [Category] 유전자 메커니즘, [키워드] activities AIDS AIDS patient Algorithm analyzed applied association atrophic gastritis cardiovascular diseases caused cellular chronic obstructive clinical implication clinically controls COPD correlated correlation COVID-19 patient deficiency defined development digestive disease Disease diagnosis Disease progression Diseases Ejection fraction Endocrine diseases expiratory expression greater Health status heterogeneity ICU immune Infection intensive care investigated involved Kidney diseases liver diseases LVEF malaria mechanical ventilatory support negative correlation Neurological disorders non-ICU patients pathway patients Perturbation presymptomatic Prognosis pulmonary disease pulmonary tuberculosis Regulation respiratory diseases severity significantly syndrome the disease Therapies transcriptome datasets transcriptomic transcriptomic data treated upregulated upregulation Variation variety ventricular Viral load Volume [DOI] 10.1155/2022/2148627 PMC 바로가기
SARS-CoV-2 infection, vaccination, and antibody response trajectories in adults: a cohort study in CataloniaArticle Published on 2022-09-162022-11-15 Journal: BMC Medicine [Category] SARS, 진단, [키워드] Adults age Analysis antibody Antibody Response asymptomatic infection benefit booster dose Breakthrough infection cardiovascular diseases Characteristics cohort study Comorbidities COVID-19 COVID-19 testing COVID-19 vaccination COVID-19 vaccines determinants disease dose Electronic health record Host IgA IgG IgG level IgG RBD IgM IgM response immune response Immunity increase in infected individuals Infection janssen Kinetics less Mental mRNA vaccine multivariable nucleocapsid antigen occurred participant predicted prevalent RBD reflected Regression analyses response responses Result SARS-CoV-2 SARS-CoV-2 antibody responses SARS-COV-2 infection SARS-CoV-2 spike Sex smoking smoking. Sociodemographic characteristics statistically significant Support trajectory vaccination Vaccine was related [DOI] 10.1186/s12916-022-02547-2 PMC 바로가기
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기